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pentobarbital will lessen the extent or impact of larotrectinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will reduce the extent or impact of atogepant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Intently. Advised atogepant dosage with concomitant usage of powerful or moderate CYP3A4